Published Research Summaries

Chronic Pain & Cannabis - Clinical Outcomes

This study examined the clinical outcomes of chronic pain patients in the UK Medical Cannabis Registry after 1, 3, and 6 months of treatment with various forms of medical cannabis. It was published December 31, 2021.
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What Do Oncologists Say About Cannabinoids & Cancer?

Published in July 2021 in the Journal Cancer Communications, this was a study that focused on which administration methods (ingest, inhale, tincture. etc.) of cannabis were preferred by the 40% of oncologists that recommended cannabis to their patients. 
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Summary of Research about Cannabinoids & Cancer

This paper includes and summarizes most of the major research on cannabinoids and cancer over the last 50 years. It was published in the Journal of Cancer Research & Clinical Oncology in July 2021. "Cannabinoids demonstrated antitumour effects both in vitro and in vivo".
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Hand with cannabis & hemp joint

Study: Terpenes & the Entourage Effect

This is a summary article of research on the bio-activity and effects of terpenes with cannabinoids. It was published in The Cannabinoid Journal online in December 2021. There are a number of points that are relevant to anyone considering cannabis products, since many include terpenes in significant amounts.
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Non-dysfunctional Cannabis Users Report Better Quality of Life than Non-Users

Published in December 2021 in the Journal of Psychiatric Research, this observational study examined quality of life among cannabis users and non-users. Cannabis users were categorized into three groups: occasional users, habitual users, and dysfunctional users. Habitual users of cannabis reported the highest quality of life scores.
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CBN Shows Promise for Glaucoma Treatment

The study showed that CBN protected mouse retinal ganglion precursor-like cells from pressure-induced toxicity. It also showed that CBN improved pattern electroretinogram (pERG) amplitudes and reduced IOP in a rat model of glaucoma.

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Whole-Plant Cannabis Drastically Reduces Treatment-Resistant Childhood Epilepsy Symptoms

This was a retrospective observational study of 10 children with epilepsy who had not responded to conventional treatment, including the FDA-approved CBD isolate drug Epidiolex.
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Cannabis & Chronic Neuropathic Pain: A Review Study

This meta-study reviewed 17 Randomized Controlled Trials (RCTs) published through 2/1/2021 studying the effects of THC, THC+CBD, CBD, CBDV, and some synthetic cannabinoids on chronic neuropathic pain.
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Cannabis Helps with Chronic Pain, Anxiety, Depression, Sleep, & Quality of Life after 3 months

"In our sample of primarily middle-aged and older adults with chronic pain, medical cannabis was associated with reduced pain intensity/inference, lower anxiety/depression, and improved sleep and quality of life."
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3 Terpenes Shown to Reduce Some Types of Neuropathic Pain

Published online ahead of print in The journal Psychopharmacology in November 2021, this mice study examined the neuropathic pain-relieving effects of three terpenes found in cannabis: Caryophyllene, Terpineol, and Terpinene.
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CBD Effective for Killing Treatment-Resistant Lung Cancer Stem Cells

Published in November 2021 in the journal Pharmaceuticals, this was an in-vitro study of the effect of CBD on lung cancer stem cells. The presence of these stem cells may explain why conventional treatments have been underwhelming in their effectiveness.
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That Skunky Cannabis Aroma is NOT from Terpenes

Cannabis and hemp flowers are known for their strong and diverse aromas, which range from earthy to sweet to "skunk-like". This study published in November 2021 in the American Chemical Society's journal, ACS Omega was looking to isolate the source of this skunky aroma, since terpenoids and terpenes are not usually associated with this scent.
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Cannabis Helps Control Endometriosis Symptoms

Published online and peer-reviewed in October 2021, this meta-study examined retrospective self-reported archival data from the Strainprint App. They focused specifically on those patients with endometriosis-associated pelvic pain.
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THC Helps Improve Traumatic Brain Injury Symptoms

In this study published online ahead of print in the journal Cannabis & Cannabinoid Research in November 2021, the authors examined the effects of THC on brain cell repair and improving short-term memory after a type of traumatic brain injury (TBI).
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CBD Study Shows Reduction in Brain & Intestinal Inflammation

This study on mice was published in the Journal of Neuroimmune Pharmacology in September 2021 and examined the effects of CBD on brain and intestinal inflammation as a result of Multiple Sclerosis as modeled by Experimental Autoimmune Encephalomyelitis (EAE).
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THC Efficacy & Tolerability Could Improve When Combined with CBD & CBG

These in-vitro study results were published in the Journal of Pain Research in late November 2021. The authors state, "The ability of cannabis to provide pain relief is well recognised".
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THC Modulates Threat-Related Brain Processing to Reduce Fear & Anxiety

This randomized, double-blind, placebo-controlled, between-subjects study was published in June 2020 in the journal Psychopharmacology. It examined the effects of low-dose THC on human brain responses to threats. 
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Study: Cannabinoid Medicines May Help with Chemotherapy-induced "Brainfog"

This meta-study was published in the journal Frontiers In Pharmacology in November 2021. It examined the phenomenon known as chemotherapy-induced cognitive impairment (CICI), commonly known as chemofog or chemobrain.
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