Cannabinoids (18)

This is a Family Tree of the major cannabinoids - scientists call it the biosynthetic pathway. All of these cannabinoids are created by the actual cannabis and hemp flowers. As you learn more about cannabinoids, please remember that cannabinoids are unique compounds that can affect people very differently. 

Please also keep in mind that many of the cannabinoids are considered BIPHASIC, meaning a small dose may have one effect, but a large does may have the opposite effect. That's why the phrase, "start LOW (dose) and go SLOW (increasing that dose)" is so important. There probably is a "sweet spot" cannabinoid amount for your goals that is likely NOT the same sweet spot as your best friend. We all have a unique body chemistry and have different expectations and goals.

 

Infographic: Cannabinoid Family Tree

 

The cannabinoid colors represent their place in The Family Tree: 

  • Stage 1: Precursor Acids (Purple)
  • Stage 2: Acids (Blue)
  • Stage 3: Neutral (Green)
  • Stage 4: Oxidized (Orange)

STAGE 1: Precursor Acidic Cannabinoids

These two acidic cannabinoids are the ancestors to all the other cannabinoids in this family tree. They specifically create other acidic cannabinoids that will be present in high concentrations in raw and cured flower. These acidic cannabinoids get "decarbed" (usually by applying heat) and turn into the neutral cannabinoids like THC and CBD. All of the acidic cannabinoids are water soluble, unlike the neutral and oxidized cannabinoids which are only soluble in oil (lipophilic).

NONE of the acidic cannabinoids are psychotropic or euphoric. ONLY a few neutral cannabinoids, namely Delta-9 THC, Delta-8 THC & THCV are psychotropic or euphoric (that we have discovered so far). 

CBG-A, Cannabigerolic Acid
Boiling Point: n/a
Reported Benefits: analgesic (pain reduction), anti-diabetic, antimicrobial, anti-tumor, antiviral, anti-inflammatory, gastrointestinal aid/nausea, hypertension relief

CBGV-A, Cannabigerovarinic Acid
Boiling Point: n/a 
Reported Benefits: anti-inflammatory (very limited research)


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STAGE 2: Acidic Cannabinoids

The stage 2 acidic cannabinoids below are the direct parents of the most well-known cannabinoids, THC and CBD. These are what The Amazing Flower actually produces itself. AFTER blooming and harvest, these acidic compounds naturally transform into the neutral cannabinoids when heated (smoking, vaporizing, or "baking").

So remember, The Amazing Flower DOES NOT actually produce ANY psychotropic or euphoric compounds! It needs help to do that. ONLY Delta-9 THC, Delta-8 THC & THCV are psychotropic/euphoric (that we have discovered so far).

CBC-A, Cannabichromenic Acid
Boiling Point: 800+ºF; will "decarb" and quickly convert to CBC at around 220ºF

Reported Benefits: analgesic (pain reduction), anti-inflammatory, antimicrobial, neurological aid

CBD-A, Cannabidiolic Acid 
Boiling Point: 600+ºF
Reported Benefits: antiemetic (reduces nausea), anti-inflammatory, antiviral, antispasmodic, anti-tumor, gastrointestinal disorder relief

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CBL-A, Cannabicyclolic Acid 
Boiling Point: 800+ºF
Reported Benefits: anti-inflammatory, anti-tumor, (very limited research) 

CBN-A, Cannabinolic Acid 
Boiling Point: 890+ºF
Reported Benefits: very little research available 

THC-A, Delta-9 Tetrahydrocannabinolic Acid

Boiling Point: n/a
Reported Benefits: antiemetic (reduces nausea), anti-inflammatory, antispasmodic, anti-tumor, antiviral, gastrointestinal aid, sedative (sleep aid) 

THCV-A, Delta-9 Tetrahydrocannabivarin Carboxylic Acid
Boiling Point: n/a
Reported Benefits: analgesic (pain reduction), anti-inflammatory, appetite suppressant, sedative (sleep aid)

Infographic: Cannabinoid Family Tree Simplified



STAGE 3: Neutral Cannabinoids (Decarboxylated, or "decarbed") 

Diagram of acidic cannabinoid molecules becoming "decarbed" by losing their carboxyl group of molecules
  

These neutralized (they are no longer acidic) cannabinoids have been studied the most and have different effects than their acidic parents. They are "fat soluble" so they don't mix well with most of the liquids humans naturally drink. If you swallow (ingest) a neutral cannabinoid, it has been shown that more of the neutral cannabinoids get into your bloodstream if you take them with fatty foods or drinks (think coffee with cream, hot chocolate).

CBC, Cannabichromene
Boiling Point: 428ºF (220ºC)

Reported Benefits: analgesic (pain reduction), anti-anxiety, antidepressant, anti-inflammatory, antimicrobial, anti-tumor, bone stimulant, neurological disorder relief, gastrointestinal disorder relief. Overview of some research is here at ScienceDirect.com.

CBD, Cannabidiol
Boiling Point: 356ºF (180ºC)
Reported Benefits: analgesic (pain reduction), anti-anxiety, antidepressant, antidiabetic (reduces blood sugar), antiemetic (reduces nausea), anti-inflammatory, antimicrobial, antispasmodic, anti-tumor, appetite stimulant, bone stimulant, gastrointestinal disorder relief, hypertension relief (high blood pressure), calming/relaxing, and possibly a sleep aid. 

CBDV, Cannabidivarin

Boiling Point: 329ºF (165ºC)
Reported Benefits: antiemetic (reduces nausea), anti-inflammatory, antispasmodic, bone stimulant, gastrointestinal disorder relief, neurological disorder relief or protectant

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CBG, Cannabigerol
Boiling Point: 126ºF (52ºC)
Reported Benefits: analgesic (pain reduction), anti-anxiety, antidepressant, antidiabetic, anti-inflammatory, antimicrobial, antispasmodic, anti-tumor, appetite stimulant, bone stimulant, hypertension relief (high blood pressure), gastrointestinal disorder relief, neurological disorder relief, sedative (sleep aid) 

CBL, Cannabicyclol
Boiling Point: 650+ºF
Reported Benefits: very little research available

THC or Delta-9 THC, Delta-9 Tetrahydrocannabinol 
Boiling Point: 315ºF (157ºC)
Reported Benefits: analgesic (pain reduction), anti-anxiety, antidepressant, antiemetic (reduces nausea), anti-inflammatory, antioxidant, antispasmodic, anti-tumor, appetite stimulant, bronchodilator, gastrointestinal disorder relief, hypertension relief (high blood pressure), neurological disorder relief or protectant, sleep apnea relief, sedative/sleep aid. 

 

THCV, Tetrahydrocannabivarin
Boiling Point: 428ºF (220ºC)
Reported Benefits: mental focus, analgesic (pain reduction), anti-inflammatory, antidiabetic (reduces blood sugar), antispasmodic, appetite suppressant, bone stimulant, neurological disorder relief or protectant

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STAGE 4: Oxidized Cannabinoids 

The oxidized cannabinoids below are just a product of time and exposure to light and oxygen. It is a natural process that makes new cannabinoids that have their own unique effects. CBN and Delta-8 THC dominant products are now widely available.

CBN, Cannabinol
Boiling Point: 365ºF (185ºC)
Reported Benefits: analgesic (pain reduction), anti-anxiety, antidepressant, anti-inflammatory, anti-microbial, antioxidant, antispasmodic, appetite stimulant, bone stimulant, neurological disorder relief or protectant, sedative (sleep aid) 

CBDL or CBND, Cannabinodiol or Cannabidinodiol
Boiling Point: 900+ºF
Reported Benefits: very limited research

Delta-8 THC, Delta-8 Tetrahydrocannabinol 

Boiling Point: 347ºF (175ºC)
Reported Benefits: analgesic (pain reduction), anti-anxiety, antidepressant, antiemetic (reduces nausea), anti-inflammatory, appetite stimulant, gastrointestinal disorder relief, neurological disorder relief or protectant


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