Key Knowledge - What's Most Important

For any patient or consumer considering a medicine or wellness product, the most important information is reliable knowledge about the effects of the active ingredients in that product, and in single servings or doses of that product. It's not really that complicated.

We all want to know:

  1. What product(s) should I take to achieve my goal(s), or outcome(s)?
  2. How much of it should I take (dose)?
  3. How effective will it be at achieving my goal?
  4. Does it have any negative side effects? 

If you can answer those questions pretty confidently, then you will have much more success and control over how well any medicine, wellness product, or supplement works for you.

What we present here is a summary, or "Cliffs Notes" version of knowledge specifically focused on active ingredients, effectiveness, administration, and dosing. That's it. There is a lot of great information and knowledge available to everyone, but rarely is it presented in a way that really tries to make the most important knowledge easier to use and understand for a patient or consumer. So, please take a look and tell us if we are on the right track. Thank you!

Here are the "Executive Summary" bullet points for this page:

  • Traditional labels of Indica, Sativa, or Hybrid have an inconsistent correlation with specific active ingredient combinations. "Strain names" also do not correlate well to consistent active ingredient combinations, even with flower from the same grower.
  • There are literally billions of possible combinations. The large number of active ingredients (Cannabinoids, Terpenes, Terpenoids, & Flavonoids) in The Amazing Flower means it will be very difficult, and take many years to develop actionable knowledge with traditional clinical trials.
  • Terpenes are important. We know from experience in the food, cosmetics, and fragrance industries that terpenes are potent, and mere tenths or hundredths of a percent can be enough to dominate a substance's smell and taste. Small variations can also have a significant effect on the way a product makes you feel.
  • Bioavailability varies a lot depending on your method of consumption. Ingesting (or inhaling) 10mg of CBD or THC will not deliver the whole 10mg of CBD or THC to your bloodstream. Swallowing (ingesting) will even deliver different cannabinoids to your bloodstream, will take longer to take effect, and will last much longer.
  • We simply don't have enough good knowledge to give patients and consumers the information they need to make well-informed buying decisions. We're trying to help with that. Anyone can quickly and anonymously share their own "anecdote", in a simple, standardized, anonymous format HERE. You will help create better, more useable knowledge in a fairly short amount of time. And we will of course publish the reports on this site for free.

 

Overview

The cannabinoids found in The Amazing Flower are completely unique to cannabis, and are not found in other plants (that we have found so far). Terpenes, Terpenoids, and Flavonoids however, occur naturally in many other types of plants, and are commonly used in the cosmetics and food industries for their scents, flavors, and colors (Flavonoids). However, we have discovered three Flavonoids that are unique to cannabis and hemp.

Traditional labels of Indica, Sativa, or Hybrid have only small correlation with consistent active ingredient combinations.  "Strain names" also do not correlate well to consistent active ingredient combinations, even with flower from the same grower (see a batch comparison further down on this page). 

We know that different active ingredient combinations result in different effects, but we have little information about which combinations work best for different objectives or desired outcomes. We hope that you will take a few minutes to learn more about the active ingredients, and start looking for the best combinations for your needs.

 

Visit our Active Ingredients Reference Guide for more information about 18 cannabinoids, 36 terpenes and terpenoids, and 14 flavonoids, including their reported effects and boiling points. If more consumers and patients would demand that product labels include ALL active ingredient amounts, we would all be much better off, and the conversation could move on from a classification system that everyone knows isn't very accurate.

So let's look at the major active ingredients

There are literally hundreds of active ingredients that The Amazing Flower is responsible for creating. The most common active ingredients have been studied to some degree, and the vast majority of those have been shown to have beneficial effects. ALL of them (except the Flavonoids) are produced in the bulbous head of the trichomes, or "resin glands" like the ones shown below growing off of the vegetation of the actual flowers.

Trichomes Close-up

The large number of active ingredients in The Amazing Flower means it will be difficult to develop actionable knowledge with traditional FDA approved randomized, placebo-controlled, double blind clinical trials. Those types of "gold-standard" studies are usually focused on just one or two active ingredients at a time, and it usually takes many YEARS to get FDA approval. 

 

To put this in perspective, consider a list of the 68 major active ingredients that are in our current Active Ingredients Guide. The label would look a lot like a multi-vitamin label, which would be great! Maybe someday. A quick calculation: If we consider 68 different active ingredients with just 10 possible values for each one, that means there are over 100 billion possible active ingredient combinations.

Since there are literally BILLIONS of different active ingredient combinations possible in The Flower, it seems prudent that we consider other viable methods to get this knowledge. If we can get people like you to anonymously share your own knowledge of what works BEST for you, all in one place, we believe we can help create valuable knowledge in a fairly short period of time.

A Strain Name or "Type" Does Not Mean Consistent Active Ingredient Profiles (Chemovars)

Despite what some retailers may tell you, an understanding of the major active ingredient combinations (profiles) in The Amazing Flower is more important than whether or not the product is labeled an "Indica", "Sativa", or "Hybrid", or has a clever "strain" name. One of the reasons why this categorization remains today is that it is not easy to deliver a consistent active ingredient profile from harvest to harvest - even in the same controlled indoor facility with the same genetics and processes.

Not to get too techy, but take a look at the graphs in the next section. They show the major active ingredient amounts from a single strain from the same vertically integrated "multi-state operator" over a period of 10 months. All product was purchased at the same retail location.

Cannabinoid Content Varies from Batch to Batch

The THC content of this single "strain" varied from around 15% to almost 25% over a period of 10 months and 14 different batch numbers.

But please do not think that just because a flower has a THC content under 20% that it is inferior to one that has over 30%. You may get more THC per dose, but if the terpene percentage is the same, you also get fewer TERPENES per dose. Say your goal is to focus and minimize memory loss and you have astutely chosen a chemovar with pinene as the dominant terpene, the 20% THC flower might be more effective. You will be getting MORE pinene per dose in milligrams. To get the same amount of THC, you can take 50% more product, and you'll get even more terpenes.

 

While that variation is significant, what is perhaps more significant is the next graph showing the major terpene content variation of those same batches.

Terpenes Vary Even More from Batch to Batch

Ever notice how some flower is so pungent that it doesn't seem to matter what container you put it in, it still stinks up the room? And then some flower doesn't seem to do that at all. The explanation is mostly total terpene content. 4% total terpene content flower will be MUCH more fragrant than 1% total terpene content flower.

Below is a graph of the 2 major terpenes in the same strain for the same batch numbers referenced in the THC graph above.

The two dominant terpenes in this single "strain" vary a lot from batch to batch, although the overall trend is positive. While these absolute percentages are small in relation to the total dry weight, the variation is over 400%. The difference between 0.2% and 0.8% of ANY terpene is significant. The result is that a consumer has a 50-50 chance of getting a very "weak" batch. That's NOT okay in any medicine or wellness product.

 

We know from experience in the food, cosmetics, and fragrance industries that terpenes are potent, and mere tenths or hundredths of a percent can be enough to dominate a substance's smell or taste. Small variations can also have a significant effect on the way that flower makes you feel.

So, it's apparent that a single professional grower has a tough time producing a consistent active ingredient profile from the same genetics. It doesn't mean they are a bad grower. It just means that it is very, very hard due to the complexity of The Flower.

Terpenes are Very Important

Terpenes in Cannabis

Our goal is to help figure out what works best for different consumer and patient goals, and we believe understanding more about terpenes is integral to that goal. They affect people differently, so the only way to really know what works best is collecting data from patients and consumers.

 

We put together a reference guide to 68 cannabinoids, terpenes and flavonoids that are most commonly found in cannabis and hemp flower. This guide of course does not include ALL the cannabinoids, terpenes, and flavonoids found in The Amazing Flower, but it covers the most frequently found active ingredients in  lab test results. There are several hundred cannabinoids, terpenes, terpenoids, and flavonoids in The Amazing Flower, and that's a big reason why it is truly amazing.

Our detailed Active Ingredient Guide here covers the major active ingredients in The Amazing Flower in more detail. It covers 68 active ingredients consistently found in high concentrations in laboratory test results, or Certificates of Analyses (COA) reports of whole flower.

Several studies have shown that a combination of many of these active ingredients together are usually more effective than a single, isolated compound. It's usually called the "Entourage Effect". Although perhaps the "Ensemble Effect" is a better term since there really are several "star" ingredients in The Amazing Flower. 

Bioavailability

Based on the best research we can find, the bioavailability varies quite a lot depending on your method of consumption. Swallowing (ingesting) or inhaling 10mg of CBD or THC product will not deliver 10mg of THC or CBD to your bloodstream.


We made a diagram that shows our bioavailability estimates based on study averages for the main methods to take cannabinoids. All of the methods usually deliver their effects for a duration of 1 to 3 hours, EXCEPT edibles, which can deliver effects for over 8 hours (more on why ingesting is different below).
And despite smoking being rated lower than vaporizing in terms of overall efficiency, some people claim that they actually need LESS product when they smoke versus when they use a vaporizer. It's really what works best for you, and you're not like anyone else, physically or chemically.

 

Swallowing or Ingesting Is Different...


...because most of the active ingredients get processed (metabolized) through the liver before they hit your bloodstream. The liver converts some active ingredients into different molecules. Delta-9 THC is mostly converted to 11-hydroxy THC. This is one reason why people say that swallowing THC gives them a very different effect than when it is taken in any other way. The effects from ingesting usually last much longer than inhaling or tincturing, too.

There have been recent advances in creating single cannabinoid (isolate) emulsions that increase the bioavailability of ingested cannabis close to over 90% before it gets to the liver. These new technologies certainly hold promise, but the research is still limited. Be very careful when dosing Nano- and Micro-emulsions. You will need a lot less than you might with a normal product designed without these technologies.

And PLEASE never forget that cannabis affects different people in very different ways. It requires some trial and error, so remember to always start low and go slow until you find the dose, administration method, and active ingredient combinations that work best for you.