Why Edibles Work Differently

The bottom line is that after D9-THC goes through the liver, it becomes 11-OH-THC which can penetrate the blood-brain barrier much more easily and efficiently. This happens to every cannabinoid that you ingest, and it's the reason why the effects can vary so significantly from using a tincture or smoking/vaping. This is a big reason why 11-OH-THC is considered more psychoactive than D9-THC.

This is a short post on LinkedIn from a pediatric pharmacist, but it gives a very concise explanation of why the THC from edibles affects you differently than the THC from all other administration methods.