This in vitro study examined the anti-inflammatory effects of the non-euphoric cannabinoids THCV, CBC, and CBN. It was published in the journal Molecules in September 2023.
While the study is fairly technical and done on human cell models (THP-1 macrophages), the results are encouraging for these three 'minor' cannabinoids. All three cannabinoids showed anti-inflammatory effects, however the cellular-level interactions were not the same for each cannabinoid.
the mitigation of the PANX1/P2X7 axis plays a significant role in the anti-inflammatory effects of THCV and CBC on NLRP3 inflammasome activation
CBN may exert its inhibitory impact on the assembly of the NLRP3 inflammasome by reducing PANX1 cleavage
THCV and CBN inhibit P-NF-κB, downregulating proinflammatory gene transcription
The authors' conclusion:
THCV, CBC, and CBN exert anti-inflammatory effects by influencing different stages of gene expression: transcription, post-transcriptional regulation, translation, and post-translational regulation.
The full text article is here at PubMed Central.
Gojani EG, Wang B, Li DP, Kovalchuk O, Kovalchuk I. Anti-Inflammatory Effects of Minor Cannabinoids CBC, THCV, and CBN in Human Macrophages. Molecules. 2023 Sep 7;28(18):6487. doi: 10.3390/molecules28186487. PMID: 37764262; PMCID: PMC10534668.