Review study concludes CBD is effective as an anti-seizure medication

Treatment resistant epilepsy and other seizure-producing encephalopathies are difficult conditions to manage, and they have a significant negative effect on patients' quality of life.

This review study aimed to collect and summarize the existing CBD research into a guide for anyone with these conditions. It was published in the Expert Opinion on Drug Metabolism and Toxicology in March 2024.

We wish we could read the full narrative review, however it is behind a significant paywall. Nonetheless, the authors state this about their work:

This exploration serves as a comprehensive guide, shedding light on a compound that holds promise for individuals contending with the significant challenges of drug-resistant epilepsy.


In general, they found that CBD in various forms had a significant effect on reducing seizure symptoms, and it also enhanced patients' cognition and overall quality of life.

Key terms and phrases used by the authors to describe their results:

  • promising
  • robust efficacy
  • cognitive benefits
  • transforming the landscape of epilepsy management


Rigorous studies reveal CBD’s robust efficacy in diverse epileptic encephalopathies, with real-world data supporting significant seizure reductions. 
Beyond seizure control, promising results emerge on the cognitive benefits of CBD, opening new avenues for its role in enhancing the overall quality of life in epileptic encephalopathies.
The therapeutic potential of CBD in epileptic encephalopathy may stem from its multifaceted mechanisms of action.


Authors' opinion:

As a promising therapeutic option, cannabidiol not only demonstrates efficacy in seizure control but also holds the potential for broader enhancements in the quality of life, especially for patients with epileptic encephalopathies.

Rigorous studies highlight cannabidiol’s efficacy, safety profile, and potential cognitive benefits, warranting further exploration for its approval in various drug-resistant epilepsy forms. 


The article abstract is here at Taylor and Francis Online.



Dell'Isola GB, Verrotti A, Sciaccaluga M, Dini G, Ferrara P, Parnetti L, Costa C. Cannabidiol: metabolism and clinical efficacy in epileptic patients. Expert Opin Drug Metab Toxicol. 2024 Mar;20(3):119-131. doi: 10.1080/17425255.2024.2329733. Epub 2024 Mar 12. PMID: 38465404.