This study examined patient-reported effects of two CBD products in managing stress. It was published in November 2023 in the journal Medical Cannabis and Cannabinoids.
All 347 participants took two different open-label (they knew the manufacturer) CBD products by tincture (oromucosal delivery) over a 30 day or 60 day period as needed to manage stress. They took a CBD isolate oil (CBD and coconut oil) for the first half, and a broad-spectrum CBD oil for the last half. So all participants tried both products.
The broad-spectrum product included 3.88% CBD, 0.094% CBG, 0.031% other cannabinoids, and some added botanical terpenes (alpha-terpinene: 0.224%, pulegone: 0.084%, (R)-(+)-limonene: 0.073%).
Most participants took a single dose once or twice per day (over 90%), while the rest used 3 or 4 doses per day.
The range of single CBD doses in the 30 day regimen group:
- 15 - 35 mg (55% of participants)
- 36 - 70 mg (35%)
- 71 - 100 mg (8%)
The range of doses used in the 60 day regimen group was similar, however more participants used only one dose per day.
The most common adverse effects reported were lethargy (1%), nausea (0.5%), and increased appetite (0.5%).
Both products showed statistically significant stress-reducing abilities. Of the participants who rated the product's ability to manage stress as a 10 out of 10, about twice as many were using the broad spectrum product.
In the authors' words:
both products were rated to be highly effective and able to assist with stress management
participants reported the broad spectrum product to be significantly more effective and better able to manage stress
There was no difference in adverse effects or quality between the products
The full text article is here at PubMed Central.
Faraj M, Dautrich T, Lundahl L, Marusak H. Effects of Two Cannabidiol Oil Products on Self-Reported Stress Relief: A Quasi-Experimental Study. Med Cannabis Cannabinoids. 2023 Nov 6;6(1):138-147. doi: 10.1159/000531886. PMID: 37942294; PMCID: PMC10629851.