Multi-cannabinoid medicine seems better than isolate for Alzheimer's Disease

Published in September 2022 in the journal Frontiers in Neuroscience, this mini review study focused on comparing multiple cannabinoid preparations with single cannabinoid isolates for their effectiveness in treating Alzheimer's Disease (AD) symptoms.

They found research supporting the effectiveness of several cannabinoids including THC, THCA, CBD, CBDA, CBG, CBC, CBN, and CBDV. However, most of the studies reported only on THC and CBD.

The authors suggest that THC rich solutions are likely more applicable for advanced AD, while CBD rich solutions might be more appropriate for preventative care in mild AD cases. They also commented on the unique biphasic nature of cannabinoids, and the importance of selecting the right dose and cannabinoid combination.

Authors' quotes:

Research suggests that cannabinoid treatments involving a combination of THC and CBD and other cannabinoids can produce greater therapeutic outcomes and less adverse effects than treatment with purified cannabinoid isolates.

THC-rich formulations may be more relevant for use in managing BPSD in people living with advanced AD, while CBD-rich preparations could have more potential when used in a prophylactic setting for preclinical, prodromal (i.e., mild cognitive impairment) or mild AD

commencing treatment in the early symptomatic phase, with multi-cannabinoid formulas low in THC (or at a 1:1 CBD:THC ratio) may result in the best therapeutic outcome for AD

cannabinoids work in a dose-dependent and biphasic manner, the dosage and ratios at which cannabinoid combinations are administered affect the overall therapeutic profile

Consideration of formulation, administration method, and dosage on a case-by-case basis will be important in the prescription of medicinal cannabis products for individuals with AD.

multi-cannabinoid combination treatment strategies are valid candidates for novel AD therapies


This study is more evidence of the "Entourage Effect" among cannabinoids. We have 59 posts on this site (as of today) that talk about this synergistic effect. Just click here or type "Entourage Effect" in the search box to learn a lot more about it.

The full text article is here at