CBD shows anti-tumor effects in colorectal cancer cells

This study investigated the cytotoxic effects of CBD in a panel (in vitro) of colorectal cancer (CRC) cells. It was published in the Journal of Cellular Biochemistry in February 2024.

CBD induced significant cytotoxicity in three different types of analysis and measurement systems.

They also examined the effect of CBD on apoptosis, paraptosis, and autophagy (different types of programmed cancer cells death).

Three different cellular markers examined suggest that CBD induces apoptosis. Four cellular markers indicated that CBD promotes paraptosis. Also, three markers showed that CBD accelerates autophagy.

"CBD activated all the forms of MAPK proteins" (mitogen-activated protein kinase) activation is "known to be involved in the induction of apoptosis, paraptosis, and autophagy."

Authors' conclusions:

CBD induced significant cytotoxicity

Our findings implied that CBD could induce CRC cell death by activating apoptosis, paraptosis, and autophagy through the activation of the MAPK pathway.

 The article abstract here here at PubMed.

Source:

Kim NY, Mohan CD, Sethi G, Ahn KS. Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells. J Cell Biochem. 2024 Feb 15. doi: 10.1002/jcb.30537. Epub ahead of print. PMID: 38358093.