CBD promotes apoptosis of osteosarcoma cells

Osteosarcoma is a common type of malignant bone tumor that often occurs in children, adolescents, and young adults. This study examined the anti-osteosarcoma effects of CBD in vitro and in vivo (mice) and was published in the American Journal of Translational Research in February 2022.

The authors provide the best summary of their findings:

"The main findings of the present study include the following:

(1) Cannabidiol suppressed the proliferation and migration of MG63 and HOS cells in a concentration-dependent manner.

(2) Cannabidiol suppressed tumor growth and promoted apoptosis via SP1-CBX2 axis in MG63 xenograft mice.

(3) Cannabidiol promoted apoptosis of osteosarcoma cells by downregulating the protein expression of CBX2.

(4) SP1 acted as an upstream transcriptional regulator of CBX2. This indicates the potential application of cannabidiol in the prevention and treatment of osteosarcoma."

They concluded that CBD promoted the apoptosis (cell suicide) of osteosarcoma cells in vitro and in vivo and suppressed tumor growth in a mouse model.

The full-text article is here at the National Library of Medicine.