The goal of this study was to determine if daily self-dosed CBD would have an impact on daytime drowsiness, low total testosterone, and liver test results. It was published online in the journal Medical Cannabis & Cannabinoids in March 2023.
Adults up to age 75 who took CBD orally for a minimum of 30 days were included in this decentralized observational study. 1,061 participants came from 49 U.S. states and their average age was about 46. Those who took THC products ("marijuana") within the last 30 days were excluded.
Participants had the choice of 3 product types:
- Full spectrum: containing all the cannabinoids, flavonoids, and terpenes commonly found in hemp oil
- Broad spectrum: containing CBD and some or all of the compounds found in hemp oil but not THC
- CBD isolate: containing only CBD
The average daily dose of CBD for all users was about 55mg, but it varied considerably. Full spectrum CBD doses were lower than single-molecule CBD isolate doses (49mg vs. 64mg). Nanoemulsions required significantly lower doses (7.6mg daily on average) and were omitted from their average dosage calculations because of this.
The single standard deviation dose range was about 18mg to 93mg of CBD per day (not including nanoemulsions). Approximately 55% of the participants had been using CBD for over 1 year. Tinctures were the most popular products used.
Daytime drowsiness was quantified using the Stanford Sleepiness Scale (SSS). Details of this scale are shown in the article (link below).
The data indicated that regular use of CBD helped significantly reduce daytime drowsiness and reduced the chances of low total testosterone in men over 40.
The authors' concluded:
CBD administration decreased DD [daytime drowsiness] and was associated with a lower prevalence of low testosterone levels in older men as compared to age-adjusted population norms
The mean daily dose of full-spectrum CBD was significantly lower than that of CBD isolate and broad-spectrum CBD
participants who used this product [formulated using nanotechnology] consumed an average daily dose that was significantly lower than all other forms of CBD
The full text article is here at PubMed Central.