CBD & CBG inhibit Mesothelioma cell growth, migration, and invasion

Published in August 2022 in the journal Cancers, this study was conducted to determine whether cannabinoids had any effect on mesothelioma tumor cells (in vitro).

Mesothelioma is a tumor in the tissue that lines the lungs, stomach, heart, and other organs. Cancerous (malignant) mesothelioma is the most common form, usually affecting the lungs. 

They tested 13 cannabinoids (THC, CBD, CBDA, CBGA, CBDV, CBG, THCV, CBN, CBC, THCA, CBDVA, CBCA, and CBCVA) in cell cultures of human and rat mesothelioma cell lines.

The results showed that all the cannabinoids exhibited some preventive effect, but CBD and CBG were the most effective. They also examined the physical mechanisms involved in inhibiting cancer cell growth:

"These effects were supported by changes in the expression of genes associated with the cell cycle, proliferation, and cell movement following CBD or CBG treatment."

"We showed that several phytocannabinoids inhibited growth of mesothelioma cells, with two phytocannabinoids, cannabidiol (CBD) and cannabigerol (CBG), being the most potent. CBD and CBG also inhibited mesothelioma cell migration and invasion."

The full text paper is here at MDPI.com.