Published in February 2022 in the journal Clinical Neuropharmacology, this is a review article examining the research primarily on CBD and THC and their impact on sleep disorders.
They found the following:
- Combining the agent oleamide (fatty amide derived from oleic acid) and THC helps stabilize respiration in all phases of sleep and helps maintain autonomic stability during sleep.
- Synthetic THC (dronabinol) was found to lower apnea-hypopnea index in a clinical investigation and regarded as safe for short-term treatment of obstructive sleep apnea.
- PTSD patients that experienced nightmares showed improvement using nabilone (an analog of dronabinol).
- CBD improved REM behavior disorder symptoms.
"Based on the available findings, cannabinoids can be used as an alternate treatment for various sleep disorders."
The review article abstract is here via Clinical Neuropharmacology.